Teach the Brain Forums

Good url retrieve from internet 10-01-05.
Take time to read even if it takes two sitting....lol
Best, URL:http://www.educarer.com/brain.htm
Rob

Well, I had hoped that I would find my answer by now...but back to the drawing board. Question: How does the synapse secure maintence of the cleft and all other parts of the synapse? By maintenance I mean keep it clean, remove old debris etc....like the glial cells support the maintenance of the neuron.
Have a nice day.....The Chargers are winning .....4th quarter......
URL: http://www.nature.com/nature/journal/v39...a0_fs.html
Be well,
Rob

I was reading an article last night titled: The synaptic vesicle protein CSP alpha prevents presynaptic degeneration....I read the abstract and it was not easy reading for me since my prior knowledge is not yet developed enough to make sense of the material...However I did find some clues: CSP alpha prevents presynaptic degeneration...the copyright date was the late l990's but I found a url for one of the authors at Harvard and e-mailed him for more information. I really did not think that it would reach him, but sure enough I received an e-mail from him. Joshua R. Sanes...he was very helpful and steered me to another long long text that he published in April 2004. I was about to find the Journal, The Neuron and now have the 26page full text in my hands....Now...I will have to go back to meet my prior knowledge terminal and built in order to read it...but I have the information...will share it with you possibly when I know what I am talking about.
Be well,
Rob

November 21, 2005...We have plenty of documented information that points to synaptic disease and motor disease which inturn means a preclusion of learning in that particular pathway. What I still cannot find out is what group of cells or cells is charged with the domestic responsibility of keeping the synapse free from debris and infestation[ie. glial cells and neurons]. At the end of October I attended an excellent conference in Cambridge, Mass. for about four days and asked many scientists the question mentioned in context.

No one knew the answer of 'what group of cells or cell is charged with the domestic responsibility of keeping the synapse free from debris and infestation]. Naturally we might suspect that glial cells do this, but there is no evidence that I can find. Astrocytes[glial] seem not to extend to the synapse, but do perform domestic duties with the individual neurons. Important maybe not......crucial to my puzzle......

If any of you know, please give me a heads up....
Thank you,
Rob

segarama Wrote: November 21, 2005...We have plenty of documented information that points to synaptic disease and motor disease which inturn means a preclusion of learning in that particular pathway. What I still cannot find out is what group of cells or cells is charged with the domestic responsibility of keeping the synapse free from debris and infestation[ie. glial cells and neurons]. At the end of October I attended an excellent conference in Cambridge, Mass. for about four days and asked many scientists the question mentioned in context.

No one knew the answer of 'what group of cells or cell is charged with the domestic responsibility of keeping the synapse free from debris and infestation]. Naturally we might suspect that glial cells do this, but there is no evidence that I can find. Astrocytes[glial] seem not to extend to the synapse, but do perform domestic duties with the individual neurons. Important maybe not......crucial to my puzzle......

If any of you know, please give me a heads up....
Thank you,
Rob

November 29, 2005
Hi,
Please note the Neuroscience Newsletter titled BRAIN WORK by the Dana Foundation....Vol. 15 No. 6 November - December 2005 Please read the Rethinking the Synapse: Emerging Science Challenges Old Assumptions by Brenda Patoine. I suggest that you subscribe to the DANA Founation's Brain Work.....url:http://www.dana.org/books/press/brainwork/

This is very exciting....
Best,
Rob

Hi....Excellent graphic of a synapse in action retrieved December 13,2005 from the internet.
Be well,
Rob URL: http://www.learner.org/channel/courses/b.../1969.html

________________________________________
December 20, 2005

Good Afternoon,
I found a very interesting slide show on the basics of neurons and synapses...it is a good refresher....retrieved from the internet 12-20-05.
Be well,
Rob URL: http://users.ipfw.edu/abbott/120/NeuronP...napse.html
December 20, 2005

January 3, 2006

The body cannot communicate from neuron to neuron unless the function of the synapse is working. It seems that we have many 'movement' disorders in the substantia nigra - striatal [basal ganglia area]...we would not be about to move at all if we had a complete collapse of our neurosynapses.
Be well,
Rob

Hi Sometimes to really get a reality check on part of the brain such as the synapse, we have to relate it to disease or something in order to get a foot hold. In this particular url retrieved 1-8-06 shows the disease of schizophrenia and the neurotransmitters that release its chemicals into the synapses. My entire purpose in showing this clip is to show the synapse and how the neurotransmitters communicate with the target neuron [usually a dendrite] on the other side of the synapse. Please watch all short clips to get a good image of the synapse....
Be well,
Rob [PLEASE REMEMBER TO TURN ON YOUR SPEAKERS]
PLEASE SCROLL DOWN A BIT AND START WITH THE BRAIN
1. Brain
2. Brain chemistry
3. Schizophrenia
URL:http://www.abilify.com/abilify/channels/...ogramName=

Hi ,

This is short and sweet....If the neuron theory is correct and it is....humans would not be able to learn or have memory without a synapse...or synapses that are replete in the brain. Think about this...if there were no synapses, there would be no communcations and learning/memory so......how does the body protect the synapse? What is synapse disease? Synapse disease sounds very serious to me....It is! What does it parts of the body does it affect?
Best,
Rob

Hi,
Well, guess how important a synapse in the brain really is....just look at what happens when a person has a serious synapse disease. Url retrieved 1-19-06 from the internet.....take some time in reading the urls that are presented.....this will really tell us how important it is to have a healthy synapse. PLEASE NOTE: , ONCE YOU HAVE OPENED THE URL WITH THE HYPERLINK, PLEASE ENTER THE FOLLOWING IN THE SEARCH BOX: Synapse Disease and THEN press search...this will show you many familar diseases under this heading....
Best,
Rob URL: http://abcnews.healthology.com/search.asp

Good Evening.....

Great picture of a synapse.....you can see almost everything needed to provide for communications to the post synaptic neuron. Url retrieved Jan. 21, 2005from the internet....
Best,
Rob URL: http://www.brainconnection.com/topics/?main=gal/synaps

Good Evening again....
Great url [pictures of synapses] retrieved 1-21-06 from the internet. You can spend some time here wondering how synaptic disease occurs....or how synapse(s) facilitate communication as per the Neuron Theory.
Best,
Rob URL: http://www.biologymad.com/NervousSystem/synapses.htm

January 24, 2006

Hi,

I understand that there is a least two types of synapses....one that is very narrow gap....for the release of chemicals.....the other synapse is wider for the neurostransmitters and electrical communication.
Retrieved Url from internet 2-1-24-06. Good read...
Be well,
Rob
URL: http://en.wikipedia.org/wiki/Synapse#Synaptic_strength

January 24, 2006
Hi ,
This is really a good read for someone who seriously wants to know about synapes in the brain...retrieved January 24, 2006 from the internet.
URL: http://users.rcn.com/jkimball.ma.ultrane...apses.html

Be well,
Rob

February 3, 2006

Morning,

EXCITABLE CELLS.... retrieved from the internet on February 3, 2006.
Good read...Url: http://users.rcn.com/jkimball.ma.ultrane...#threshold
Rob

March 5, 2006
Morning,

If a disease destroyed dopaminergic neurons in the brain...there would be destroying the synapse also....what does that mean.....Almost everything!!!!!
Best,
Rob

March 13, 2006

Good Morning

Joseph LeDoux author of The Emotional Brain also wrote The Synaptic Self: How Our Brains Become Who We Are..... The Synaptic self is equally as good as the Emotional brain and if you have not read them both, your prior knowledge as a practitioner will respect you for it......The Synaptic self sells for about $29.95@2002; ISBN 0-670-03028-7......These two books are musts to keep your prior learning which is a phyical change in the brain up to snuff. Quoting from the beginning of the text by Bart Simpson, " Dad what is the mind? Is it just a system of impulses or something tangible?"

March 13, 2006

Good Morning

Joseph LeDoux author of The Emotional Brain also wrote The Synaptic Self: How Our Brains Become Who We Are..... The Synaptic self is equally as good as the Emotional brain and if you have not read them both, your prior knowledge as a practitioner will respect you for it......The Synaptic self sells for about $29.95@2002; ISBN 0-670-03028-7......These two books are musts to keep your prior learning which is a physical change in the brain up to snuff. Quoting from the beginning of the text by Bart Simpson, " Dad what is the mind? Is it just a system of impulses or something tangible?"
Be well,
Rob

Good Evening,

We have reviewed action potential that being the electrical current that propagates to the axon terminal. Then all of a sudden the neurotransmitter places chemicals in the synaptic clef headed for the post synaptic receiver....those chemicals are sometimes SSRI....or dopaminergic agonists etc.....the post synaptic receptor [many times the dendrite]will accept the chemical only if the receptor is programmed to do so.....Synaptic potential is the chemical portion of the Neuron doctrine and action potential is the electric portion of the same.

Be well,
Rob

April 10, 2006
Good Morning,

Well with all the searching and asking questions regarding who maintains the healthy cleanup of the synapes in the brain and other locations, it seems that it is the glial cells after all. Of course recently I was told by big time professionals that glial cells were really not important. The problem is that we cannot live without their functions. It seems that many many neuroscientists have taken a long holiday from the cells and the brain.......We must realize that we cannot live without the formation of synapes in the brain and body.....these thank goodness are recognized as still very important. My case with glial cells is simple....very few professionals have kept up in the study of this cell that out numbers the neuron by at least 10 to 1 in the brain.My purpose is clear, just how important are these cells. Especially when they are communicating with each other and with neurons. Be well,
Rob

April 11, 2006

Good Afternoon,

We are continually making the case for the importance of this gap between neurons called the synapse. An interesting read may be had at the origin of the internet article with the hyperlink of http://www.sciencedaily.com/print.php
Best,
Rob

April 28, 2006
Good morning,

If you really think about it, really really think about it, the synapse which for a better explanation is that gap between neurons that defines itself very well in the Neuron Theory....that little synapse which is vital for communications and learning and memory dissapears with synapse disease. Therefore the self contained neuron has no place to communicate, send messages externally from the purview of the neuron itself...if the neuron cannot get the message of learning and memory out through the synaptic gap to other receiving neurons....how does memory continue, how does learning continue and how does life continue.....
Be well,
Rob

segarama Wrote:April 28, 2006
Good morning,

If you really think about it, really really think about it, the synapse which for a better explanation is that gap between neurons that defines itself very well in the Neuron Theory....that little synapse which is vital for communications and learning and memory dissapears with synapse disease. Therefore the self contained neuron has no place to communicate, send messages externally from the purview of the neuron itself...if the neuron cannot get the message of learning and memory out through the synaptic gap to other receiving neurons....how does memory continue, how does learning continue and how does life continue.....
Be well,
Rob

__________________
June 12, 2006
Good Morning

Would you be surprised that the so called neural support cell called the Glial Cell...(which it is a support cell, but much more) has a great deal to do with the synapse....finally I have found the search answer to whom cleans the synaptic gap. The astrocyte does...(glial of course). We also know now that the glial cell has a great deal to communicating with the neurons and much to do with the synapse. I will expatiate this once I get over my excitement of all the things that the glial cell can do.....no more just the neuron....we have an important cell with glia; especially in synaptogenesis.

Best,
Rob

Hi Rob,

If you are interested in neuron-glia interactions, check out the recent article, "Purinergic signalling in neuron-glia interactions," which can be retrieved from:
http://www.ncbi.nlm.nih.gov/entrez/query...med_docsum

Truly fascinating...

Cheers,
Christina